OU Medicine

Michael Businelle, PhD

Director, Oklahoma Tobacco Research Center

Michael S. Businelle, Ph.D., is a Peggy and Charles Stephenson Endowed Chair in Cancer, Co-Director of the Oklahoma Tobacco Research Center, Director of mHealth Shared Resource, and Associate Professor (tenured) in the Department of Family and Preventive Medicine at OU Medicine. He is the founding director of the NCI-designated Stephenson Cancer Center mHealth Shared Resource.


Over the past four years, Businelle's team has developed the Insight mHealth platform, which enables researchers to rapidly create mobile applications that can utilize EMA and sensor data to identify environmental, cognitive, affective, physiological, and behavioral antecedents of health risk behaviors (e.g., smoking, heavy alcohol use, poor diet / inactivity / obesity, etc.) and deliver context-specific JITAIs in real-time.


Businelle is PI on three ongoing NIH funded studies including mHealth applications that focus on smoking cessation (R01CA221819), alcohol cessation (R34AA024584), and case management (R01MD010733). He is MPI on an additional R01 proposal that aims to use a smartphone application to support marijuana cessation efforts among adults with Marijuana Use Disorder. His goal is that the research will improve understanding of the causes of health disparities and ultimately lead to effective smartphone based just-in-time adaptive interventions (JITAIs) that reduce health disparities.


Degree-Granting Institutions
Lousiana State University, Baton Rouge, LA, PhD, 2007, Clinical Psychology

Postgraduate Training
Postdoctoral Fellowship, Cancer Prevention Research, University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2009
Clinical Psychology Resident, G.V. (Sonny) Montgomery Veterans Affairs Medical Center and the University of Mississippi Medical Center, Jackson , MS, 2006 - 2007

Grant Funding:

Principal Investigator

R01CA221819 (PI: Businelle)
NIH/NCI (Clinical Trials#: NCT03740490)
Smartphone Based Smoking Cessation Intervention for Socioeconomically Disadvantaged Adults
Direct & Indirect: $2,695,044 (Direct: $1,858,651)

R01MD010733 (PIs: Businelle & Reingle)
NIH/NIMHD (Clinical Trials#: NCT03399500)
mHealth to Increase Service Utilization in Recently Incarcerated Homeless Adults
Direct & Indirect: $3,326,084 (Direct: $2,627,219)

R34AA024584 (PIs: Businelle & Walters) 06/01/2018–05/31/2020
NIH/NIAAA (Clinical Trials#: NCT03746808)
Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking
among Homeless Adults
Direct & Indirect: $665,384 (Direct: $515,108)

TSET 092-016-0002 (PIs: Businelle & Kendzor)
Oklahoma Tobacco Research Center
Direct & Indirect: $3,800,000 (Direct: $3,454,545)

OUHSC Pilot Funds (PI: Businelle; NCT03405129)
Project Phoenix: Pilot Intervention for Smokers Who Are Not Ready to Quit Smoking
Direct & Indirect: Start-up funds


R01CA231952 (PIs: D. Vidrine & J. Vidrine)
Partnering with a State Food Bank to Provide Tobacco Treatment to Underserved Smokers

P30 CA225520 (PI: Mannel; Businelle: Director mHeath Shared Resource)
Stephenson Cancer Center – Cancer Center Support Grant
Total Direct: $7,000,000

U01 DA045537 (PI: Wagener) 8/01/2018–07/31/2020
Switching to the SREC: Evaluating Risk Reduction among Quitline Treatment Failures
Total Direct ($998,213) and Total Costs ($1,489,354)

R01CA197314 (PI: Kendzor)
Small Financial Incentives to Promote Smoking Cessation in Safety Net Hospital Patients
Total Direct ($1,127,995) and Total Costs ($1,619,450)

R21DA046333 (PIs: Wagener & Villanti)
Addiction and Behavior Related to Menthol Cigarette Substitutes
Total Direct Costs: $427,742

R01CA197314 Supplement (PI: Kendzor)
NIH/NCI Supplement
Mobile Contingency Management for Smoking Cessation Among Socioeconomically Disadvantaged Adults
Total Direct ($80,550)


R01CA221819-01A1S1 (PI: Businelle mentoring Ashley Cole)
The Application of a Smartphone-Based Smoking Cessation Tool with American Indian Adults
Total costs: $327,562

K01HL148907 (PI: Alayna P. Tackett)
Respiratory effects of E-Cigarette use among Youth: A prospective, longitudinal investigation

K99DA046564 (PI: Emily Hébert)
Using Machine Learning to Develop Just-in-Time Adaptive Interventions for Smoking Cessation
Direct & Indirect: $179,883

F31DA047015 (PI: Samantha Schiavon)
Balanced Placebo Design with Varenicline: Pharmacological and Expectancy Effects on Medication Adherence
Direct Costs: $102,223

Selected Publications:

Businelle, M. S., Ma, P., Kendzor, D. E., Frank, S., Vidrine, D. J., & Wetter, D. W. (2016). An ecological momentary intervention for smoking cessation: Evaluation of feasibility and effectiveness. Journal of Medical Internet Research, 18, e321. (PMC5187451)


Businelle, M. S., Ma, P., Kendzor, D. E., Frank, S., Wetter, D. W., & Vidrine D. J. (2016). Using intensive longitudinal data collected via mobile phone to detect imminent lapse in smokers undergoing a scheduled quit attempt. Journal of Medical Internet Research, 18, e275. (PMC5088341)


Businelle, M. S., Kendzor, D. E., Reitzel, L. R., Costello, T. J., Cofta-Woerpel, L., Li, Y., Mazas, C. A., Vidrine, J. I., Cinciripini, P. M., Greisinger, A. J., & Wetter, D. W. (2010). Mechanisms linking socioeconomic status to smoking cessation: A structural equation modeling approach. Health Psychology, 29, 262-273. (PMC2922845)


More research publications


Businelle Lab


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