Michael Businelle, PhD

Director of the mHealth Shared Resource at Oklahoma Tobacco Research Center at the Stephenson Cancer Center, Associate Professor, Department of Family and Preventive Medicine

Dr. Michael Businelle is an Associate Professor in the Department of Family and Preventive Medicine at the University of Oklahoma Health Sciences Center (OUHSC) and a member of the NCI Designated Stephenson Cancer Center (SCC). He was recruited to the OUHSC in October 2015 to develop and direct the SCC Mobile Health (mHealth) Shared Resource. The mHealth resource is staffed by 4 programmers, a program manager, and a research technician. In the past 2 years, has led the development of the InsightTM mHealth platform. The InsightTM platform enables researchers to rapidly create mobile applications that can utilize ecological momentary assessments (EMA) and sensor data (i.e., activity monitor, mobile carbon monoxide monitor, e-cigarette device) to identify environmental, cognitive, affective, physiological, and behavioral antecedents of cancer risk behaviors (e.g., smoking, heavy alcohol use, poor diet / inactivity / obesity, etc.) and deliver context-specific adaptive interventions in real-time. The mHealth resource currently supports over 20 studies (2 studies collected data outside the US – Cambodia, and Scotland).

            Since 2011, Dr. Businelle has been the PI on 10 intervention studies that have been funded by the NIH, ACS, and internal funds and he has a strong publication record (i.e., over 100 peer reviewed publications) in the areas of smoking cessation, health disparities, and mHealth. Nine of these studies include collection of EMA data to identify mechanisms of health risk behaviors in socioeconomically disadvantaged samples. This information has been used to develop novel interventions that automatically tailor treatment content based upon an individual’s current symptoms/needs. In upcoming studies, Dr. Businelle plans to integrate real-time wearable sensor data (e.g., smoking, eating, drinking gestures) to inform intervention algorithms.


Degree-Granting Institutions
Lousiana State University, Baton Rouge, LA, PhD, 2007, Clinical Psychology

Postgraduate Training
Postdoctoral Fellowship, Cancer Prevention Research, University of Texas MD Anderson Cancer Center, Houston, TX, 2007 - 2009
Clinical Psychology Resident, G.V. (Sonny) Montgomery Veterans Affairs Medical Center and the University of Mississippi Medical Center, Jackson , MS, 2006 - 2007

Grant Funding:

1) 1R01MD010733-01A1 (PIs: Businelle & Reingle) 
mHealth to Increase Service Utilization in Recently Incarcerated Homeless Adults
This 3-armed randomized clinical trial will use an innovative smartphone application to identify and address barriers that prevent recently incarcerated homeless adults from obtaining available case management, crisis management, substance abuse, and mental health services.
Direct & Indirect: $3,326,084 (Direct: $2,627,219)
Effort: 30%

2) 5R34AA024584-02 (PIs: Businelle & Walters)  
Development and Testing of a Just-in-Time Adaptive Smart Phone Intervention to Reduce Drinking among Homeless Adults
The aims of this study are to identify predictors of heavy drinking and develop and test a just-in-time adaptive intervention to prevent heavy drinking days in a sample of homeless adults with Alcohol Use Disorder.
Direct & Indirect: $665,384 (Direct: $515,108)
Effort: 20%

3) 1P30 CA225520-01 (PI: Mannel; Director mHeath Shared Resource: Businelle)
05/01/2018 – 04/30/2023
Stephenson Cancer Center – Cancer Center Support Grant
Dr. Businelle is the Scientific Director of the NCI designated Stephenson Cancer Center mHealth Shared Resource. The shared resource enables researchers to rapidly create mobile applications that identify environmental, cognitive, affective, physiological and behavioral antecedents of cancer risk behaviors (e.g., smoking, heavy alcohol use, poor diet, inactivity, obesity, etc.) and deliver context-specific adaptive interventions in real time.
Total Direct: $1,400,000
Effort: 10%

4) 1R01CA197314-01 (PI: Kendzor, Co-I: Businelle) 
Small Financial Incentives to Promote Smoking Cessation in Safety Net Hospital Patients
This randomized clinical trial will examine the longer-term effects of offering small financial incentives for confirmed smoking abstinence in safety-net hospital patients who are seeking smoking cessation treatment. In addition, traditional and ecological momentary assessments will be used to identify antecedents of smoking lapse.
Total Direct ($1,127,995) and Total Costs ($1,619,450)
Effort: 10%

5) 1R01CA197314-01 Supplement  (PI: Kendzor, Co-I: Businelle)
NIH/NCI Supplement
Mobile Contingency Management for Smoking Cessation Among Socioeconomically Disadvantaged Adults
The purpose of the supplement is to 1) develop a fully automated, mobile phone-based CM approach that can remotely verify smoking abstinence, confirm participant identity, and deliver financial incentives for smoking cessation, and 2) evaluate the feasibility and preliminary effectiveness of using a fully automated mobile CM approach as an adjunct to telephone counseling and nicotine replacement therapy among socioeconomically disadvantaged adults.
Total Direct ($80,550)
Effort: 10% year 1; in kind years 2-3

6) Project SmartPath  (PI: Kendzor, Co-I: Businelle) 
OUHSC Pilot Funds
Evaluation of a Smartphone Intervention to Reduce Sedentary Behavior
The aims of the study are to 1) evaluate the efficacy of a “real-time” smartphone intervention that works in conjunction with a wearable activity monitoring device to reduce sedentary time via smartphone prompts during prolonged sedentary bouts (relative to 2 comparison groups [AO and EQ]) and 2) to identify treatment mechanisms and contextual factors associated with sedentary behavior using traditional and ecological momentary assessment approaches.
Direct & Indirect: OUHSC funds

7) PARTNERS Foundation  (PI: Santa Maria, Consultant: Businelle)
MY-RID: Motivating Youth to Reduce Infections and Disconnections
Role: Consultant
Using a participatory research model, a personalized nurse-led, mobile enhanced, HIV prevention intervention for youth experiencing homelessness and unstably housing will be developed. Once developed and beta tested, we will conduct a small randomized attention control trial to assess the feasibility, acceptability, and preliminary efficacy of the intervention.
Direct & Indirect: $100,000

8) U01DA045537 (PI: Wagener, Co-I: Businelle)
12/01/2017 – 11/30/2019
Switching to the SREC: Evaluating Risk Reduction among Quitline Treatment Failures
The specific aims of this project are to use a novel smartphone application to: 1) assess nicotine SREC vs. placebo SREC on product switching/substitution, craving/withdrawal, abuse liability, number of cigarettes smoked, and perceived nicotine dependence, 2) evaluate changes in biomarkers of tobacco constituent exposure and physiological effects, and 3) evaluate which e-cigarette device characteristics and perceived effects influence complete (vs. partial or no substitution).
Direct and Indirect Costs: $1,683,437

Selected Publications:

*Neisler, J., Reitzel, L. R., Garey, L., Kendzor, D. E., *Hebert, E. T., Vijayaraghavan, M., & §Businelle, M. S. (2018). The moderating effect of perceived social support on the relation between heaviness of smoking and quit attempts among adult homeless smokers. Drug & Alcohol Dependence, 190, 128-132.

Businelle, M. S. (Co-First Author), Reingle Gonzalez, J. M. (Co-First Author), Kendzor, D. E., Staton, M., North, C. S., & Swartz, M. D. (2018). Using mHealth to increase treatment utilization among recently incarcerated homeless adults (Link2Care): Protocol for a randomized controlled trial. JMIR Research Protocols, 7, e151.

Santa Maria, D., Padhye, N., Yang, Y., Gallardo, K., & Businelle, M. (in press). Predicting sexual behaviors among homeless young adults using ecological momentary assessment: Results of Project Youth EMA. Journal of Medical Internet Research Public Health and Surveillance.

Santa Maria, D., Padhye, N. S., Yang, Y., Gallardo, K. G., Santos, G. M., Jung, J. & §Businelle, M. S. (in press). Drug use patterns and predictors among homeless youth: Results of an ecological momentary assessment. The American Journal of Drug and Alcohol Abuse.

*Koslovsky, M. D., *Hébert, E. T., Swartz, M. D., Chan, W., Leon-Novelo, L., Wilkinson, A. V., Kendzor, D. E., & §Businelle, M. S. (in press). The time-varying relations between risk factors and smoking before and after a quit attempt. Nicotine & Tobacco Research.

Suchting, R., *Hébert, E. T., Ma, P., Kendzor, D. E., & §Businelle, M. S. (in press). Using elastic net penalized cox proportional hazards regression to identify predictors of imminent smoking lapse. Nicotine & Tobacco Research.

*Neisler, J., Reitzel, L. R., Garey, L., Kendzor, D. E., Hébert, E. T., Vijayaraghavan, M., & §Businelle, M. S. (2018). Concurrent nicotine and tobacco product use among homeless smokers and associations with cigarette dependence and other factors related to quitting. Drug & Alcohol Dependence, 185, 133-140.

*Hébert, E. T., *Stevens, E., Frank, S., Kendzor, D. E., Wetter, D.W., Zvolensky, M. J., Buckner, J. D., §Businelle, M. S. (2018). An ecological momentary intervention for smoking cessation: the associations of just-in-time, tailored messages on smoking lapse risk factors. Addictive Behaviors, 78, 30-35.

Kendzor, D. E., Allicock, M., Businelle, M. S., Sandon, L., Gabriel, K. P., & Frank, S. G. (2017). Evaluation of a shelter-based diet and physical activity intervention for homeless adults., (vol. 14, pp. 88-97). Journal of Physical Activity & Health. PMID: 27775471

*Peltier, M. R., *Lee, J., *Ma, P., Businelle, M. S., Kendzor, D. E. (2017). The influence of sleep quality on smoking cessation in socioeconomically disadvantaged adults., (vol. 66, pp. 7-12). Addictive behaviors. PMID: 27855299. DOI: 10.1016/j.addbeh.2016.11.004.

Businelle, M. S., *Ma, P., Kendzor, D. E., Frank, S. G., Wetter, D. W., Vidrine, D. J. (2016). Using Intensive Longitudinal Data Collected via Mobile Phone to Detect Imminent Lapse in Smokers Undergoing a Scheduled Quit Attempt., (10th ed., vol. 18, pp. e275). Journal of medical Internet research. PMID: 27751985. PMCID: PMC5088341.

Businelle, M. S., *Ma, P., Kendzor, D. E., Frank, S., Vidrine, D. J., & Wetter, D. W. (2016). An ecological momentary intervention for smoking cessation: Evaluation of feasibility and effectiveness., (vol. 18, p. e321). Journal of medical Internet research. PMC5187451.

Kendzor, D. E., Shuval, K., Gabriel, K. P., Businelle, M. S., *Ma, P., High, R. R., *Cuate, E. L., *Poonawalla, I. B., *Rios, D. M., Demark-Wahnefried, W., Swartz, M. D., & Wetter, D. W. (2016). Impact of a mobile phone intervention to reduce sedentary behavior in a community sample of adults: A quasi-experimental evaluation., (vol. 18, p. e19). Journal of medical Internet research. PMC4746437

*Ma, P., Kendzor, D. E., *Poonawalla, I. B., Balis, D. S., & Businelle, M. S. (2016). Daily nicotine patch wear time predicts smoking abstinence in socioeconomically disadvantaged adults: An analysis of ecological momentary assessment data., (vol. 169, pp 64-67). Drug & Alcohol Dependence. PMID: 27776246

*Taylor, E., Kendzor, D. E., Reitzel, L. R., & Businelle, M. S. (2016). Health risk factors and desire to change among homeless adults., (vol. 40, pp. 455-460). American Journal of Health Behavior. PMID: 27338992

*Kish, D., Reitzel, L. R., Kendzor, D. E., *Okamoto, H., & Businelle, M. S. (2015). Characterizing concurrent tobacco product use among homeless cigarette smokers., (vol. 17, pp. 1156-1160). Nicotine & Tobacco Research. PMID: 25358660

Businelle, M. S., *Poonawalla, I. B., Kendzor, D. E., *Rios, D. M., *Cuate, E. L., *Savoy, E. J., *Ma, P., Baggett, T. P., Reingle, J., & Reitzel, L. R. (2015). Smoking policy change at a homeless shelter: attitudes and effects., (vol. 40, pp. 51-6). Addictive behaviors. PMID: 25222848. DOI: 10.1016/j.addbeh.2014.08.013.

Kendzor, D. E., Businelle, M. S., *Poonawalla, I. B., *Cuate, E. L., *Kesh, A., *Rios, D. M., Ma, P., Balis, D. S. (2015). Financial incentives for abstinence among socioeconomically disadvantaged individuals in smoking cessation treatment., (vol. 105, pp. 1198-1205). American Journal of Public Health. PMID: 25393172

*Kish, D., Reitzel, L. R., Kendzor, D. E., *Okamoto, H., & Businelle, M. S. (2015).

Nguyen, M. A., Reitzel, L. R., Kendzor, D. E., & Businelle, M. S. (2015). Perceived cessation treatment effectiveness, medication preferences, and barriers to quitting among light and moderate/heavy homeless smokers. Drug and Alcohol Dependence, 153, 341-345. (PMID: 26072221)

*Childress, S., Reitzel, L. R., Santa Maria, D., Kendzor, D. E., *Moisiuc, A., & Businelle, M. S. (2015). Mental illness and substance use problems in relation to homelessness onset. American Journal of Health Behavior, 39, 549-555. (PMID: 26018103)

Businelle, M. S., *Ma, P., Kendzor, D. E., Reitzel, L. R., Chen, M., Lam, C., Bernstein, I., & Wetter, D. W. (2014). Predicting quit attempts among homeless smokers seeking cessation treatment: An ecological momentary assessment study. Nicotine & Tobacco Research, 16, 1371-1378. (PMC4207873)

Businelle, M. S., Kendzor, D. E., *Kesh, A., *Cuate, E. L., *Poonawalla, I. B., Reitzel, L. R., Okuyemi, K., & Wetter, D. W. (2014). Small financial incentives increase smoking cessation in homeless smokers: A pilot study. Addictive Behaviors, 39, 717-720. (PMID: 24321696)